Carbapenems versus Piperacillin-tazobactam or cefepime in the treatment of AmpC producing Enterobacterales bacteraemia.
Outcomes of treating AmpC producing Enterobacterales bacteraemia with Carbapenems versus Non-carbapenems.
Rédigé par : Dr Jean-Pierre Bru
AmpC β-lactamases are found in Enterobacter species, Serratia species, Citrobacter freundii, Providencia species and Morganella morganii (‘ESCPM’). Exposure to β-lactams may cause derepression of AmpC β-lactamase gene leading to hyperproduction of AmpC β-lactamases (which are cephalosporisases), that will hydrolyse third generation cephalosporins. Carbapenems remain stable against AmpC β-lactam...
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