Continuous infusion of cefotaxime lead to better PK target attainment versus intermittent infusion in critically ill patients.

To date, only two observational studies on cefotaxime dosing in critical care populations are available, none of them compared continuous versus intermittent dosing. They showed that conventional intermittent dosing frequently yields inadequate drug concentrations in ICU. The aim of this study was to ascertain which dosing regimen of cefotaxime results in the most rapid and persistent target at...