Continuous infusion of vancomycin is less toxic than intermittent infusion. It’s time to act.
Retrospective multicentre matched cohort study comparing safety and efficacy outcomes of intermittent-infusion versus continuous-infusion vancomycin.
Rédigé par : Dr Jean-Pierre Bru
Numerous consensus guidelines recommend intermittent-infusion vancomycin (IIV) at 15–20 mg/kg every 8–12 h in patients with complicated Staphylococcus aureus infections, and trough concentrations of 15-20mg/L as surrogate marker for AUC24/MIC≥400mg.h/L. The incidence of vancomycin-associated nephrotoxicity in patients with troughs of 15–20mg/L is approximately 20%. The objective of the study wa...
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