Does Colistin-Meropenem combination therapy reduce the emergence of colistin resistance vs. Colistin monotherapy?

Colistin is one of a limited number of options for the treatment of carbapenem-resistant Gram-negative bacteria. A previously published randomized controlled trial (RCT) compared colistin monotherapy with colistin-meropenem combination for the treatment of severe infections caused by carbapenem-resistant, colistin-susceptible Gram-negative bacteria. No difference was found in clinical failure o...