Is it time to administer ceftriaxone as continuous infusion in critically ill patients?

Population pharmacokinetics of ceftriaxone administered as continuous or intermittent infusion in critically ill patients.

  • Leegwater E. et al.
  • Rédigé par : Dr Jean-Pierre Bru
Ceftriaxone has a long half-life of approximately 8.5 h, owing a once daily administration. But in critically ill patients, the probability of reaching a pharmacodynamic target of 100% T>MIC with conventional intermittent dosing regimens is unclear. The objective of the study was to determine the population pharmacokinetics of unbound ceftriaxone via continuous versus intermittent infusion, ...
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