Lefamulin versus moxifloxacin for the treatment of community-acquired bacterial pneumonia. Results of a phase III trial.

Efficacy and Safety of Intravenous-to-oral Lefamulin, a Pleuromutilin Antibiotic, for the Treatment of Community-acquired Bacterial Pneumonia: The Phase III Lefamulin Evaluation Against Pneumonia (LEAP 1) Trial.

  • File TM. et al.
  • Rédigé par : Dr Jean-Pierre Bru
Lefamulin is a pleuromutilin antibiotic. Its name comes from the pleuromutilin-producing fungus Pleurotus mutilus. Previous pleuromutilin are already used : tiamulin and valnemulin were introduced to veterinary medicine in 1979 and 1999, and retapamulin was approved (FDA 2007) as a topical agent for the treatment of non-severe cutaneous infections. Pleuromutilin inhibits bacterial protein synt...
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