(1, 3)-β-D-glucan (BDG) is a major cell-wall constituent of most pathogenic fungi. It is widely used as a surrogate marker to support the early diagnosis of several invasive fungal infections (IFI), including candidemia. Despite high negative predictive value, some false negative of BDG are reported. The clinical relevance and the potential prognostic role of persistently negative BDG in adults...
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