Suboptimal dosing of fluconazole in critically ill patients.

Fluconazole is frequently used for treatment of invasive Candida infections in critically ill patients as primary therapy or early “step down therapy”. The aim was to study the impact of renal function on the population pharmacokinetics (PK) of fluconazole in critically ill patients with varying degrees of renal function or undergoing continuous renal replacement therapy (CRRT). The reference...