In patients with septic shock, it is likely that meropenem should be used with a loading dose and higher doses than recommended. ( Kothekar AT, et al. )

Clinical pharmacokinetics of 3 h extended infusion of meropenem in adult patients with severe sepsis and septic shock: implications for empirical therapy against Gram negative bacteria

| Dr Olivier Leroy

Meropenem break points for enterobacteriacea, P. aeruginosa and A. baumannii, range from 2 to 8 mg/l.  The usual recommended doses … Suite