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Oral doxycycline or ceftriaxone for the treatment of Lyme neuroborreliosis? ( Kortela E. et al. )

Oral doxycycline compared to intravenous ceftriaxone in the treatment of Lyme neuroborreliosis: a multicentre, equivalence, randomized, open-label trial.

24 mar | Dr Jean-Pierre Bru

Lyme neuroborreliosis (LNB) is often treated with intravenous ceftriaxone, although oral doxycycline has been suggested to be non-inferior to ceftriaxone … Suite

H. pylori eradication reduce the risk of gastric cancer in high risk patients. ( Choi IJ. et al. )

Family History of Gastric Cancer and Helicobacter pylori Treatment.

10 mar | Dr Jean-Pierre Bru

Helicobacter pylori infection and a family history of gastric cancer are the main risk factors for gastric cancer. However, whether … Suite

In patients with septic shock, it is likely that meropenem should be used with a loading dose and higher doses than recommended. ( Kothekar AT, et al. )

Clinical pharmacokinetics of 3 h extended infusion of meropenem in adult patients with severe sepsis and septic shock: implications for empirical therapy against Gram negative bacteria

03 mar | Dr Olivier Leroy

Meropenem break points for enterobacteriacea, P. aeruginosa and A. baumannii, range from 2 to 8 mg/l. The usual recommended doses … Suite

In units with high rates of resistance empirical use of colistin in the treatment of late ventilator-associated pneumonia cannot be recommended. ( Cisneros JM. et al. )

Colistin versus meropenem in the empirical treatment of ventilator-associated pneumonia (Magic Bullet study): an investigator-driven, open-label, randomized, noninferiority controlled trial.

27 fév | Dr Olivier Leroy

Multidrug-resistant gram-negative bacilli (MDR-GNB), including Pseudomonas aeruginosa, Acinetobacter baumannii, and extended-spectrum beta-lactamase (ESBL)-producing or carbapenemase-producing Enterobacteriaceae, are currently the pathogens … Suite

The role of ¹⁸F-FDG-PET/CT in the diagnosis of left-sided endocarditis: native vs. prosthetic valves. ( de Camargo RA. et al. )

The Role of ¹⁸F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in the Diagnosis of Left-sided Endocarditis: Native vs Prosthetic Valves Endocarditis.

25 fév | Dr Jean-Pierre Bru

Studies have suggested that the addition of 18F-FDG-PET/CT might improve the accuracy of the modified Duke Criteria among patients with … Suite

Carbapenems versus Piperacillin-tazobactam or cefepime in the treatment of AmpC producing Enterobacterales bacteraemia. ( Tan SH. et al. )

Outcomes of treating AmpC producing Enterobacterales bacteraemia with Carbapenems versus Non-carbapenems.

13 fév | Dr Jean-Pierre Bru

AmpC β-lactamases are found in Enterobacter species, Serratia species, Citrobacter freundii, Providencia species and Morganella morganii (‘ESCPM’). Exposure to β-lactams … Suite

Latent tuberculosis infection: the 4-month course of rifampicin is safer than the 9-month course of isoniazid ( Jonathon R Campbellet al )

Adverse events in adults with latent tuberculosis infection receiving daily rifampicin or isoniazid: post-hoc safety analysis of two randomised controlled trials

06 fév | Pr Pierre Tattevin

Different regimens have similar efficacy for the treatment of latent tuberculosis infection (LTI), including 3 months of isoniazid (INH)/rifampicin (RMP), … Suite

ESBL-producing pyelonephritis : piperacillin-tazobactam is as effective as carbapenems. ( Sharara SL, et al. )

Is Piperacillin-Tazobactam Effective for the Treatment of Pyelonephritis Caused by ESBL-producing Organisms?

04 fév | Dr Philippe Lesprit

The use of alternatives to carbapenems (CP) for the treatment of infections caused by extended-spectrum β-lactamase (ESBL)-producing bacteria is the subject … Suite

Continuous infusion of vancomycin is less toxic than intermittent infusion. It’s time to act. ( Kang CK, et al. )

Retrospective multicentre matched cohort study comparing safety and efficacy outcomes of intermittent-infusion versus continuous-infusion vancomycin.

30 jan | Dr Jean-Pierre Bru

Numerous consensus guidelines recommend intermittent-infusion vancomycin (IIV) at 15–20 mg/kg every 8–12 h in patients with complicated Staphylococcus aureus infections, … Suite

Sepsis incidence and mortality in the world ( Kristina E Rudd, et al )

Global, regional, and national sepsis incidence and mortality,1990–2017: analysis for the Global Burden of Disease Study

28 jan | Dr Jean-Pierre Bru

No estimates were previously available for the global incidence of sepsis and mortality from this disorder. Methods Authors used data … Suite