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When the infection is related to a femoral catheter, it seems essential that empirical antibiotic therapy should cover the non-fermenting Gram-negative bacilli. ( Niccolò Buetti et al. )

The insertion site should be considered for the empirical therapy of short-term central venous and arterial catheter-related infections.
| Dr Olivier Leroy

The current guidelines on management of intravascular catheter-related infections recommend that empiric therapy should be individualized according to the patient’s … Suite  

Adjunction of inhaled amikacin to intravenous standard-of-care antibiotics do not modified short term prognosis of Ventilator Associated Pneumonia due to Gram-negative bacilli. ( Niederman MS. et al. )

Inhaled amikacin adjunctive to intravenous standard-of-care antibiotics in mechanically ventilated patients with Gram-negative pneumonia (INHALE): a double-blind, randomised, placebo-controlled, phase 3, superiority trial.
| Dr Olivier Leroy

The ESCMID recommendations published in 2017 (ATB-VAC 31/5/2017) are clear: the use of inhaled antibiotics in ICU should be prohibited. … Suite