In patients with septic shock, it is likely that meropenem should be used with a loading dose and higher doses than recommended.

Clinical pharmacokinetics of 3 h extended infusion of meropenem in adult patients with severe sepsis and septic shock: implications for empirical therapy against Gram negative bacteria

  • Kothekar AT, et al.
  • Rédigé par : Dr Olivier Leroy
Meropenem break points for enterobacteriacea, P. aeruginosa and A. baumannii, range from 2 to 8 mg/l.  The usual recommended doses for severe infections are 1g/8h (with the exception of meningitis and cystic fibrosis infections).  For optimal bactericidal activity for carbapenems, the plasma concentration must remain above the MIC for the pathogen for at least 40% of dosing interval (fT &...
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