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Is it time to administer ceftriaxone as continuous infusion in critically ill patients? ( Leegwater E. et al. )

Population pharmacokinetics of ceftriaxone administered as continuous or intermittent infusion in critically ill patients.

31 mar | Dr Jean-Pierre Bru

Ceftriaxone has a long half-life of approximately 8.5 h, owing a once daily administration. But in critically ill patients, the … Suite

Pulmonary diffusion of dalbavancin could allow its use in the treatment of pneumonia ( Rappo U. et al. )

Epithelial Lining Fluid and Plasma Concentrations of Dalbavancin in Healthy Adults after a Single 1,500-Milligram Infusion.

26 mar | Dr Olivier Leroy

Pneumonia is frequently caused by gram-positive cocci including S. aureus and S. pneumoniae. Dalbavancin is effective against these pathogens and … Suite

Oral doxycycline or ceftriaxone for the treatment of Lyme neuroborreliosis? ( Kortela E. et al. )

Oral doxycycline compared to intravenous ceftriaxone in the treatment of Lyme neuroborreliosis: a multicentre, equivalence, randomized, open-label trial.

24 mar | Dr Jean-Pierre Bru

Lyme neuroborreliosis (LNB) is often treated with intravenous ceftriaxone, although oral doxycycline has been suggested to be non-inferior to ceftriaxone … Suite

Adjunction of inhaled amikacin to intravenous standard-of-care antibiotics do not modified short term prognosis of Ventilator Associated Pneumonia due to Gram-negative bacilli. ( Niederman MS. et al. )

Inhaled amikacin adjunctive to intravenous standard-of-care antibiotics in mechanically ventilated patients with Gram-negative pneumonia (INHALE): a double-blind, randomised, placebo-controlled, phase 3, superiority trial.

19 mar | Dr Olivier Leroy

The ESCMID recommendations published in 2017 (ATB-VAC 31/5/2017) are clear: the use of inhaled antibiotics in ICU should be prohibited. … Suite

Lobar or segmental consolidation are valid criteria for invasive pulmonary aspergillosis. ( Herbrecht R. et al. )

Validation by real-life data of the new radiological criteria of the revised and updated consensus definition for invasive fungal diseases.

17 mar | Dr Jean-Pierre Bru

The European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium (EORTC/MSGERC) consensus … Suite

H. pylori eradication reduce the risk of gastric cancer in high risk patients. ( Choi IJ. et al. )

Family History of Gastric Cancer and Helicobacter pylori Treatment.

10 mar | Dr Jean-Pierre Bru

Helicobacter pylori infection and a family history of gastric cancer are the main risk factors for gastric cancer. However, whether … Suite

In patients with septic shock, it is likely that meropenem should be used with a loading dose and higher doses than recommended. ( Kothekar AT, et al. )

Clinical pharmacokinetics of 3 h extended infusion of meropenem in adult patients with severe sepsis and septic shock: implications for empirical therapy against Gram negative bacteria

03 mar | Dr Olivier Leroy

Meropenem break points for enterobacteriacea, P. aeruginosa and A. baumannii, range from 2 to 8 mg/l. The usual recommended doses … Suite

In units with high rates of resistance empirical use of colistin in the treatment of late ventilator-associated pneumonia cannot be recommended. ( Cisneros JM. et al. )

Colistin versus meropenem in the empirical treatment of ventilator-associated pneumonia (Magic Bullet study): an investigator-driven, open-label, randomized, noninferiority controlled trial.

27 fév | Dr Olivier Leroy

Multidrug-resistant gram-negative bacilli (MDR-GNB), including Pseudomonas aeruginosa, Acinetobacter baumannii, and extended-spectrum beta-lactamase (ESBL)-producing or carbapenemase-producing Enterobacteriaceae, are currently the pathogens … Suite

The role of ¹⁸F-FDG-PET/CT in the diagnosis of left-sided endocarditis: native vs. prosthetic valves. ( de Camargo RA. et al. )

The Role of ¹⁸F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in the Diagnosis of Left-sided Endocarditis: Native vs Prosthetic Valves Endocarditis.

25 fév | Dr Jean-Pierre Bru

Studies have suggested that the addition of 18F-FDG-PET/CT might improve the accuracy of the modified Duke Criteria among patients with … Suite

Acyclovir may improve the prognosis of patients with an elevated HSV viral load during ventilator-associated pneumonia not responding to antibiotic treatment. ( Schuierer L. et al. )

Impact of acyclovir use on survival of patients with ventilator-associated pneumonia and high load herpes simplex virus replication.

18 fév | Dr Olivier Leroy

Herpes simplex virus (HSV) replication can be detected in the respiratory secretions of a high proportion of ventilated intensive care … Suite

International News Antibiotherapy Antifungal treatments Antimicrobial stewardship Flash news ICU

International News
Antibiotherapy Antifungal treatments Antimicrobial stewardship Flash news ICU