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Is it time to administer ceftriaxone as continuous infusion in critically ill patients? ( Leegwater E. et al. )

Population pharmacokinetics of ceftriaxone administered as continuous or intermittent infusion in critically ill patients.

31 mar | Dr Jean-Pierre Bru

Ceftriaxone has a long half-life of approximately 8.5 h, owing a once daily administration. But in critically ill patients, the … Suite

Continuous infusion of vancomycin is less toxic than intermittent infusion. It’s time to act. ( Kang CK, et al. )

Retrospective multicentre matched cohort study comparing safety and efficacy outcomes of intermittent-infusion versus continuous-infusion vancomycin.

30 jan | Dr Jean-Pierre Bru

Numerous consensus guidelines recommend intermittent-infusion vancomycin (IIV) at 15–20 mg/kg every 8–12 h in patients with complicated Staphylococcus aureus infections, … Suite

Continuous infusion of cefotaxime lead to better PK target attainment versus intermittent infusion in critically ill patients. ( Aardema H. and al. )

Continuous versus intermittent infusion of cefotaxime in critically ill patients: a randomized controlled trial comparing plasma concentrations.

16 jan | Dr Jean-Pierre Bru

To date, only two observational studies on cefotaxime dosing in critical care populations are available, none of them compared continuous … Suite